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Global Nutrition Address 150 Allens Creek Road, Rochester, New York 14618 585-360-2159
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Balanced DHEA supports all of the tissues that respond to androgens, and is an antagonist for cortisol and other glucocorticosteroid hormones. Optimal levels of DHEA, a natural steroid hormone that is synthesized by the adrenal glands, support healthy heart function, immune function, brain function, bone metabolism, blood lipid metabolism, energy metabolism, the regulation of normal blood sugar and insulin levels, and the maintenance of lean body mass. Mood and healthy sexual response is also affected by proper DHEA function in both men and women.
Supports steroid hormones production as a precursor for estrogens, and testosterone and other androgens. Increases lean body mass & decreases adipose tissue mass. Support balanced immune system function. Promotes vitality, sense of well being & mood. Promotes healthy function of bone, heart, brain, muscles and other androgen responsive tissues. Enhanced stamina and general strengthening. May use with or without testosterone to support healthy androgen function.
More Info
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Types: 60 caps (price shown) or 50g powder. You must login or register in order to view product options and prices for each.
New and Improved Brain Vitale!
Brain Vitale™ by Designs for Health has just become even better. The former Brain Vitale contained the two powerful brain revitalizing nutrients, Acetyl Carnitine and PhosphatidylSerine (PS), both capable of repairing brain neurons. These two ingredients are now reinforced with the mind-body nutrient GPC (GlyceroPhosphoCholine). GPC is a unique osmo-protectant, raises choline and generate unique omega-3 phospholipids to build cell membranes, and is a clinically proven brain revitalizer. These three brain supernutrients are assisted by Ginkgo biloba extract, which enhances the brain protection. The Phytosome® form of Ginkgo is at least twice as effective. Along with inositol, another key osmo-protectant and a precursor for second messenger action within the nerve cells, you have one amazing brain formula. Dr. Parris Kidd gives this formula a “thumbs up” and says, “This sets the standard for effective brain formulas.”
Benefits of Brain Vitale:
Helps relieve depression
Increases memory
Repairs damaged neurons
Slows the progression of Alzheimer’s disease
Helps reverse senility
Protects the brain from damage caused by stress
Relieves emotional and physical stress
Promotes mental alertness
Clinical Applications of Brain Vitale:
Mental alertness: ¼-1 tsp or 2-7 capsules per day
Improved short and long term memory: ½-1 tsp or 4-7 capsules per day
Increased learning capacity: ½ -1 tsp or 4-7 capsules per day
Alzheimer's Disease: ½ -1 tsp. or 4-7 capsules per day
Stroke victims: ½-1 tsp or 4-7 capsules per day
Senility: 1 tsp or 6-7 capsules per day
Depression: 1 tsp or 6-7 capsules per day
Suggested Use: Take 1-7 capsules per day with meals or take one half teaspoon (1.5 grams) per day with meals or as directed by your health care practitioner.
Brain Vitale Capsule
Size: 60 capsules
Each 2 capsules contains:
Acetyl L-Carnitine 500 mg
GlyceroPhosphoCholine (GPC) 200 mg
Inositol 200 mg
Phosphatidylserine 120 mg
GinkgoSelectTM PhytosomeTM 90 mg
[Ginkgo biloba (leaves) and Glycine (soybeans)]
Other Ingredients: Gelatin (capsule).
Brain Vitale Powder
Size: 50 grams/33 servings per container
Each one-half teaspoon (1.5 grams) contains:
Acetyl-L-Carnitine 500 mg
GlyceroPhosphoCholine (GPC) 200 mg
Inositol 200 mg
Phosphatidylserine 120 mg
GinkgoSelect™ Phytosome™ 90 mg
[Ginkgo Biloba (leaves) and Glycine (soybeans)]
Store In A Cool, Dry Place. Keep Out Of Reach Of Children
WARNING: Consult with your health care practitioner before use if you are pregnant or lactating, have had chronic kidney failure or are taking prescription medication, especially blood thinning medication.
This product does not contain wheat, yeast, gluten, eggs, dairy, corn, artificial colors, flavors, sugars, or preservatives.
Read Customer questions and answers about Mental Health in our FAQ.
Research on GPC shows
* Naturally occurring in all our cells and mother's milk
* Unique type of metabolic protectant
* "Active" form of choline - has an added phosphate and glycerol group
* Water soluble and can cross the blood brain barrier (PC cannot)
* Effectively raises acetylcholine
* Improvements in attention,mental focus and cognition even if linked to Alzheimer's or poor brain circulation
* Numerous studies showing increased brain recovery following stroke or other injury
* Revitalizes master hormone functions from pituitary control in the elderly (growth hormone)
* Studies used 1200 mg per day in divided doses
* The largest stroke trial in Italy, 2000 patients, GPC helped 95% to improve
* GPC outperforms other cholinergic precursors: better than choline, PC, and citicholine (known as CDP choline)
What does ALC (Acetyl L-Carnitine) do?
* Critical energy cofactor for brain cells
* REPAIRS physically damaged neurons
* Helps stroke victims
* Helps prevent age related memory decline
* Increases learning capacity
* Enhances immune function
What does Ginkgo do?
* Improves microcirculation to the brain cells
* Helps enhance short and long term memory
* Helps improve mood
* Supports mental focus and energy
* Helps revitalize fading memory
* Protects the brain from stress induced neuronal death
* Balances catecholamine, serotonin and cortisol levels
* Phytosome® form is at least two times as bioavailable, with enhanced degree of efficiency
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Can Brain Vitale be used with medications?
There have never been any contraindications found with the use of Acetyl-L-Carnitine,Phosphatidyl Serine, and known medications. Brain Vitale is often combined with anti-depressant medications with only positive results. This is because these two nutrients are natural to the body’s metabolism, and their effects are only positive on overall brain health and wellness.
Are there any side effects to this product?
Taken late in the day, this product may cause difficulty falling asleep due to its brain energizing properties.
Is there anyone who should not take Brain Vitale?
People with seizure disorders or epilepsy should avoid brain-energizing nutrients such as Acetyl-L-Carnitine.
How long will it take before I start feeling the effects of Brain Vitale?
Due to the instant assimilation of these nutrients when taken in powder form, you will feel results in as little as 20 minutes.
Improving Memory and Reversing Senility
Over thirty studies show that Acetyl-L-Carnitine slows or prevents age related decline in mental function.1 1.5 g/day of Acetyl-L-Carnitine given to 236 older adults for forty-five days significantly increased the effectiveness of performance on all the measures of cognitive functioning, memory performance, and constructional thinking.2 Twenty adults given 1.5 g of Acetyl-L-Carnitine experienced reversal of many of the signs of brain aging.3 Alcoholics with cognitive impairment have also benefited from Acetyl-L-Carnitine.4
Relieving Depression
Acetyl-L-Carnitine is one of the most valuable compounds for relieving depression naturally.5,6 It does so through increasing the energy of brain cells. Energy allows brain cells to communicate better, and a social brain is a happier brain. Acetyl-L-Carnitine also increases levels of compounds such as Acetylcholine, which is essential for healthy mood levels.
Speeding Stroke Recovery
One hundred sixty patients who had suffered from a stroke a year or more ago were given 1.5 g of Acetyl- L-Carnitine a day for eight weeks. This led to increased speed of recovery, as well as improved mood and attention span.7
Slowing Alzheimer's
Thirty Alzheimer's patients given Acetyl-L-Carnitine for 6 months saw dramatically less mental deterioration.8 One year treatment with Acetyl- L-Carnitine in 130 patients with Alzheimer's also led to a slower rate of mental decline in 13 of the 14 outcome measures.9 A total of over 600 patients with Alzheimer's have been studied in over twenty years of research,10 confirming that Acetyl-L-Carnitine benefits Alzheimer's patients.11-13 Acetyl-L-Carnitine may also be of benefit in the management of Parkinson's disease.14
Helping Damaged Nerves and Diabetic Neuropathy
Animal models of sciatic nerve injury show that Acetyl-L-Carnitine dramatically increases the speed of nerve healing and prevents loss of nerve function.15 Acetyl-L-Carnitine should be considered in all cases where physical injury to neurons occurs, including brain injuries from car accidents and other causes.16 Those with brain injuries report that Acetyl-L-Carnitine-especially when combined with phosphatidyl serine-significantly improves overall brain function, attention span, and learning ability. Acetyl- L-Carnitine has also been found helpful in the management of diabetic neuropathy17 especially when combined with lipoic acid and GLA.18
Immune System
Acetyl-L-Carnitine has also been found to be a powerful immune enhancer. This is due to its ability to promote the health of the nervous system, which in turn governs the activity of the immune system. Acetyl-L-Carnitine may offer specific to HIV patients.19,20 and those with tuberculosis.
How Phosphatidyl Serine (PS) benefits Memory and Recall
Memories are formed when a group of brain cells-neurons-talk to each other. Together, neurons create a memory of an event, such as where the keys are, where you put the remote control, or where you parked the car. In order for memories to be both formed and recalled, neurons must talk to each other. Without PS, such communication among neurons is difficult if not impossible. With PS, neurons communicate more effectively. That is why PS has such positive effects on memory, recall, and overall brain function.
Helping Age Related Memory Loss
As we age, most of us lose some memory function. PS may help to reverse or slow this process.21-23 Seventy-five patients with age-related memory impairment were given 300 mg of PS per day for 12 weeks. PS led to improved performance tests related to learning and memory tasks of daily life.24 Another study of thirty-three patients with dementia showed equally promising results. This 8-week study of 300 mg per day of PS showed that PS can significantly improve overall brain wellness in those with dementia.25
Slowing Alzheimer's Disease
Alzheimer's disease is a debilitating ailment that destroys the memory of older adults. While there is no cure for Alzheimer's, nutrients like PS may help slow the progression and even reverse some of the symptoms of this disease.26-28 Eighteen patients with Alzheimer's disease given 400 mg of PS per day for 6 months experienced a wide range of positive effects on memory and recall.29 Twenty-five patients with Alzheimer's disease given 300 mg of PS for 12 weeks also saw improvements in brain function. This study also showed that PS may have the most benefit when given in early stages of Alzheimer's.30
Relieving Depression
The effects of phosphatidyl serine on cognitive, affective and behavioral symptoms were studied in a group of 10 elderly women with depressive disorders. Patients were treated with placebo for 15 days, followed by PS at 300 mg/ day for 30 days. PS induced consistent improvement of depressive symptoms, memory and behavior.31
How to Take PS
As with any brain-energizing nutrient, PS is best avoided near bedtime as it may prevent sleep. It is best taken with or before breakfast and lunch. If you are taking PS to treat any medical condition, or are taking medications, especially psychotropic medications, it is advisable to take PS with the guidance of your health care practitioner. PS is derived from soy, and is suitable for vegetarians. The beneficial level of intake of PS according to human research is anywhere from 100- 800 mg per day. Most studies in humans where PS has been used to optimize brain function used 300 mg of PS per day. After an initial loading phase with PS, long term supplementation at l00 mg per day may be sufficient for most adults to maintain optimal brain levels of PS.
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Research Review
Ginkgo biloba prevents mobile phone-induced oxidative stress in rat brain.
Clin Chim Acta. 2004 Feb;340(1-2):153-62.
Ilhan A, Gurel A, Armutcu F, Kamisli S, Iraz M, Akyol O, Ozen S.
BACKGROUND: The widespread use of mobile phones (MP) in recent years has raised the research activities in many countries to determine the consequences of exposure to the low-intensity electromagnetic radiation (EMR) of mobile phones. Since several experimental studies suggest a role of reactive oxygen species (ROS) in EMR-induced oxidative damage in tissues, in this study, we investigated the effect of Ginkgo biloba (Gb) on MPinduced oxidative damage in brain tissue of rats.RESULTS: Oxidative damage was evident by the: (i) increase in malondialdehyde (MDA) and nitric oxide (NO) levels in brain tissue, (ii) decrease in brain superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities and (iii) increase in brain xanthine oxidase (XO) and adenosine deaminase (ADA) activities. These alterations were prevented by Gingko biloba treatment. Furthermore, Gb prevented the MP-induced cellular injury in brain tissue histopathologically.
CONCLUSION: Reactive oxygen species may play a role in the mechanism that has been proposed to explain the biological side effects of mobile phone, and Ginkgo biloba prevents the Mobile Phone-induced oxidative stress to preserve antioxidant enzymes activity in brain tissue.
Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment. Stackman RW, Eckenstein F, Frei B, Kulhanek D, Nowlin J, Quinn JF.
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239-3098, USA. stackman@ohsu.edu
Alzheimer's disease (AD) is characterized by cognitive decline and deposition of beta-amyloid (Abeta) plaques in cortex and hippocampus. A transgenic mouse AD model (Tg2576) that overexpresses a mutant form of human Abeta precursor protein exhibits age-related cognitive deficits, Abeta plaque deposition, and oxidative damage in the brain. We tested the ability of Ginkgo biloba, a flavonoid-rich antioxidant, to antagonize the age-related behavioral impairment and neuropathology exhibited by Tg2576 mice. At 8 months of age, 16 female Tg2576 and 15 female wild-type (wt) littermate mice were given ad lib access to tap water or Ginkgo biloba (70 mg/kg/day in water). After 6 months of treatment, all mice received Morris water maze training (4 trials/day for 10 days) to assess hippocampal dependent spatial learning. All mice received a 60-s probe test of spatial memory retention 24 h after the 40th trial. Untreated Tg2576 mice exhibited a spatial learning impairment, relative to wt mice, while Ginkgo biloba-treated Tg2576 mice exhibited spatial memory retention comparable to wt during the probe test. Spatial learning was not different between Ginkgo biloba-treated and untreated wt mice. There were no group differences in learning to swim to a visible platform. Soluble Abeta and hippocampal Abeta plaque burden did not differ between the Tg2576 groups. Brain levels of protein carbonyls were paradoxically elevated in Ginkgo biloba-treated mice. These data indicate that chronic Ginkgo biloba treatment can block an age-dependent decline in spatial cognition without altering Abeta levels and without suppressing protein oxidation in a transgenic mouse model of AD.
Ginkgo biloba normalises stress-elevated alterations in brain catecholamines, serotonin and plasma corticosterone levels.
Eur Neuropsychopharmacol. 2003 O;13(5):321-5. Shah ZA, Sharma P, Vohora SB.
Department of Medical Elementology and Toxicology, Faculty of Science, Hamdard University, 110 062 New Delhi, India.
Stress and depression and associated mental health problems have increased tremendously in modern times. The search for effective and safe alternatives from natural sources especially plant products should, therefore, continue. Forced immobilization is one of the best explored models of stress in rats and the role of corticosterone, serotonin and catecholamines, i.e. norepinephrine (NE), dopamine (DA) is well documented. Numerous studies have shown that Ginkgo biloba has antioxidant and neuroprotective properties and utility in cerebrovascular insufficiency and impaired cerebral performance. We investigated the effect of G. biloba on whole brain catecholamine, serotonin and plasma corticosterone levels following 1, 2 and 4 h restraint stress using HPLC and also plasma corticosterone using luminescence spectrophotometry. G. biloba extract (14 mg/kg p.o.) restored restraint stress-induced elevation in whole brain levels of catecholamines (NE, DA), 5-HT and plasma corticosterone to near normal levels. Further studies are warranted to explore the clinical potential of this encouraging lead in the management of stress and to elucidate the mechanisms involved.
Click here to download Brain Vitale PDF File
Click HERE: for Brain Vitale Research References More Info
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Size: 8 oz You must login or register in order to view prices for this product.
CarniClear™ supersaturated carnitine liquid is a pleasant naturally flavored non-acidic liquid form of carnitine, is available in an 8oz bottle. This product is the most affordable way of delivering the multi-gram dosing of carnitine that is most often recommended.
In addition to the pure base L-carnitine, CarniClear™ contains small amounts of highly purified glycerine and 500 mcg of vitamin B12 and 100 mg of vitamin B5 (Pantothenic Acid). Vitamin B5 is added to support a necessary step in fat metabolism, the synthesis of Coenzyme A, which is essential for the transport of fat by l-carnitine. Vitamin B12 is an important cofactor in many metabolic pathways, including endogenous carnitine synthesis. Diets low in animal meat are very deficient in Vitamin B12, as well as carnitine.
L-Carnitine is a compound naturally occurring in all foods but significant amounts are only found in dark meats (due to high concentration of mitochondria), for example: lamb (190mg/4 oz), beef (143mg/4 oz), poultry(13mg/4 oz), fish (3-10mg/4 oz).
Carnitine supplementation may be needed especially for vegetarian diets or when dark meats are consumed in small amounts because neither preformed carnitine nor its precursor amino acids are ingested in adequate amounts to support optimal health.
Serving Size 5 full droppers (5 ml)
Each serving contains:
L-Carnitine 2500 mg
Vitamin B12 500 mcg
Pantothenic Acid 100 mg
Other ingredients: Vegetable glycerin, deionized water, raspberry and mint natural flavors.
Recommended Use
As a dietary supplement, take 5 full droppers (2.5 g carnitine) daily or as directed by your health care practitioner.
Store In A Cool, Dry Place. Keep Out Of Reach Of Children.
This product does not contain wheat, yeast, soy, gluten, eggs, dairy, corn, artificial colors, flavors, sugars, or preservatives.
Read Customer questions and answers about Weight Loss in our FAQ.
Research Review
Designs for Health, which for many years has been a leading supplier of carnitine products to the medical community, is pleased to announce a new delivery form of this important nutrient to our proud line of carnitine products:
1. Supersaturated L-Carnitine liquid: CarniClear™ (raspberry/mint flavor) 2500 mg per teaspoon
2. Highly concentrated powder: L-Carnitine Tartrate (pleasant lemon-like tart flavor), 2800 mg per teaspoon
3. Carnitine Synergy capsules: 400 mg elemental Carnitine from L-Carnitine Tartrate combined with 100 mg Acetyl-L-Carnitine
High pharmaceutical standards of production ensure the highest purity and quality of these carnitine products.
Pure base carnitine is carnitine in its natural state not bound to anything. For carnitine to be supplied as a powder, it must first be bound to an acid such as tartaric or fumaric acid.
Vitamin B5 was added to support a necessary step in fat metabolism, the synthesis of Coenzyme A, which is essential for the transport of fat by L-Carnitine.
Vitamin B12 is an important cofactor in many metabolic pathways, including endogenous carnitine synthesis. Diets low in animal meat are deficient in Vitamin B12, as well as carnitine.
L-Carnitine is a compound naturally occurring in all foods, but significant amounts are only found in dark meats (due to high concentration of mitochondria), for example: lamb (190 mg/4 oz), beef (143 mg/4 oz), poultry(13 mg/4oz), fish (3-10 mg/4oz), cheese( 1-13 mg/4oz), rice (0.3 mg/4oz), tomato (0.1 mg/4oz). Approximately 20 mg/day of Carnitine is synthesized in the human body (kidney and liver) from methionine and lysine, requiring other cofactor nutrients such as iron, vit C, vit B3 and B6. Many metabolic states may require more than this synthesized amount. See below. Carnitine supplementation may be needed especially for vegetarian diets or when dark meats are consumed in small amounts, because neither preformed carnitine nor its precursor amino acids are ingested in adequate amounts to support optimal health.
How to Take Carnitine
In general, L-Carnitine will be absorbed faster and with higher peak plasma when ingested on an empty stomach, because it does not compete for absorption with other amino acids or peptides. When taken on an empty stomach, plasma levels of carnitine will remain elevated for 3-4 hours. If high blood concentrations throughout 24 hrs are desired, carnitine
Carnitine would be especially useful to take right before exercise, for both resistance and endurance training. When taken with meals, it will achieve a lower but more prolonged elevated plasma level, about 7-8 hours, supporting at first the metabolism of the fat ingested with meals and subsequently that of the fat released from the adipose tissue.
It's important to keep in mind that when consuming an excessively high carbohydrate diet, fat release from the adipose tissue is impaired by high levels of insulin. In this case, fat cannot be transported into the mitochondria with the help of carnitine and burned, because it does not have a chance to get in the bloodstream in the first place. The only benefit that L-carnitine can have in this case, would be to support the transport of the fat absorbed from the meals into the mitochondria for burning. As a result, carnitine may reduce the chance of gaining body fat, during a diet high in carbohydrates and fat, but fat loss is very unlikely in this metabolic situation. So, in order to maximize fat loss and benefit from L-carnitine supplementation, the amount of daily carbohydrate intake should be minimized and adjusted to match general activity levels and exercise type and duration.
L-carnitine absorption and retention in muscle is enhanced by phosphatidyl choline (available from DFH in the form of Phosphatidyl Choline 40%, Phosphatidyl Choline softgels and Krill Oil).(7)
Carnitine supplementation in the amount of 1-6 g/day was shown to provide metabolic support for the following:(7)
Many metabolic states that require an enhanced oxidation of fat, such as: excess body fat, high triglycerides, sustained exercise (aerobic or resistance training), low carbohydrate/high fat diets.
A variety of conditions that require an intensive support of the heart muscle and the immune system cells.
Other conditions such as: ADHD, pregnancy, infant nutrition, low sperm motility, chronic fatigue, Raynaud's syndrome, dialysis complications
Side-effects from: interferon therapy for Hepatitis C, HIV anti-virals or chemotherapy
Carnitine supports the metabolism of fat during weight loss diets.
L-Carnitine is an indispensable nutrient that supports the transport of fat into the part of the cell (the mitochondria), where it can be burned and converted into energy. See Fig 1 on the reverse side of this flier. Several studies have shown that L-carnitine supplementation improves the body's efficiency to burn fat, even if the subjects are not overtly deficient in carnitine.((2))
One study investigated the effect of 4 weeks of supplementation with 1g L-carnitine, three times per day on 100 overweight patients following a diet of 1200 Kcal/day. The carnitine group lost an average of 9.7 lb vs - 7.8 lb in the placebo group. So, L-carnitine supplementation supported the weight loss process with an additional 2.1 lb in 1 month. The authors concluded that "the study supports the assumption formulated on the basis of other studies that carnitine supplementation leads to increased desirable weight loss, over and above diet and exercise".(3) Authors have also emphasized that L-carnitine's metabolic advantage will be especially realized when administered along with a regimen that ensures a caloric deficit through adequate diet plus exercise. Special attention should be given to the amount of carbohydrate ingested.
Another study showed that supplementation with L-Carnitine increased the loss of fat in the urine, in addition to increasing the fat burning for energy.(7) This shows two different venues in which L-carnitine provides a metabolic advantage.
Carnitine supports the preservation of lean body mass, especially during anaerobic exercise and fat loss.
It is especially important to preserve the lean body mass during fat loss in order to prevent a reduction in metabolic rate. Carnitine supplementation was shown in several studies to support an actual increase in lean body mass, in addition to reducing the amount of exercise-induced muscle tissue damage.(11) This benefit applies to both resistance and endurance type exercises. This means that carnitine supplementation prior to a workout results in less muscle soreness.
Carnitine supports the metabolism of fat during exercise and spares carbohydrate stores.
Fat burning is intensified during endurance exercise, and L-Carnitine was shown to increase the efficiency of this process, allowing the body to tap more into the fat stores than into the sugar stores (the blood glucose or the glycogen from liver and muscles).(5, 13) In other words, for any given amount of calories burned in an exercise bout, more calories will be derived from fat then from sugar if supplemented with L-Carnitine. This will also reduce the chance of becoming hypoglycemic during exercise and reduce the likelihood of sugar cravings afterward.
Carnitine supports enhanced exercise performance.
L-carnitine was shown to improve exercise performance, probably by enhancing the delivery of fat fuel to the muscles. 4 g per day of LCarnitine, over a period of 2 weeks increased a typical marker of aerobic capacity (VO2 max) by 6 %.(12) It was also shown to increase the anaerobic threshold, and so delay the event where the muscles feel a "burn" from lactic acid.
Carnitine supports the heart muscle and related conditions: congestive heart failure, ischemia, myopathy.
"L-Carnitine is a useful therapeutic agent for the treatment of congestive heart failure in combination with traditional pharmacological therapy."(6) This is probably due to the fact that L-Carnitine is supporting the delivery of fat to the heart muscle, which is its main fuel source. A review of the literature emphasizes the results of the three trials with carnitine, which have shown significant benefits for patients with myocardial ischemia.(9)
Carnitine supports the normalization of blood lipids: triglycerides, HDL, Lp(a).
"Serum-lipid concentrations were determined in patients treated with 900 mg/day. Serum-triglyceride was significantly reduced and concentrations continued to decline as carnitine administration continued."(10) "1 g per day of L-Carnitine over a period of 10-15 weeks caused a substantial increase in HDL."(14)
One study found L-carnitine to lower serum triglycerides by 28%, total cholesterol by 12%, while raising HDL by 12%. [15, 16] Another study concluded: "from a general sample of 3525 cardiopathic patients treated with 2 g daily of L-Carnitine during 1 year...after 12 months of administration only 282 patients showed abnormal levels of cholesterolemia."(9)
"L-Carnitine (2 g/day) significantly reduced Lp(a) levels (-7.7% versus baseline and -11.7% vs placebo treatment), the reduction being more dramatic in the subjects with the more marked elevations. In a significant number of subjects, the reduction of Lp(a) resulted in a return of this major cardiovascular risk parameter to the normal range."(4)
Carnitine supports various conditions.
"Conditions which seem to benefit from supplementation of L-carnitine include anorexia, chronic fatigue, coronary vascular disease, diphtheria, hypoglycemia, male infertility, muscular myopathies, pregnancy and Rett syndrome. In addition, preterm infants, dialysis patients, and HIV+ individuals seem to be prone to a deficiency of L-carnitine, and benefit from supplementation...under some experimental conditions pretreatment has favored aerobic processes and resulted in improved endurance performance."(8)
Click here to download L-Carnitine PDF File: The Metabolic Support Nutrient
Murray R, Granner D., Mayer. Harper’s Biochemistry PA, 23-rd Edition.1993
Muller DM, Seim H. Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults. Metabolism 2002 Nov;51(11):1389-91.
Lurtz R., Fischer R. Carnitine as supporting agent in weight loss in adiposity. Medical Journal for natural Therapy, 39, 1(1998) pg 12-15.
Sirtori CR, Calabresi L. L-carnitine reduces plasma lipoprotein(a) levels in patients with hyper Lp(a). Nutr Metab Cardiovasc Dis. 2000 Oct;10(5):247-51.
Kiens B, Roepstorff C Utilization of long-chain fatty acids in human skeletal muscle during exercise Acta Physiol Scand. 2003 Aug;178(4):391-6.
Kobayashi A, Masumura Y, L-carnitine treatment for congestive heart failure--experimental and clinical study. Jpn Circ J. 1992 Jan;56(1):86-94.
Hongu N, Sachan DS.Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism. J Nutr. 2003 Jan;133(1):84-9.
Kelly GS. L-Carnitine: therapeutic applications of a conditionally-essential amino acid. Altern Med Rev. 1998 Oct;3(5):345-60.
Fernandez C, Proto C. [L-carnitine in the treatment of chronic myocardial ischemia. An analysis of 3 multicenter studies and a bibliographic review] Clin Ter. 1992 Apr;140(4):353-77.
Maebashi M, Kawamura N, Sato M . Lipid-lowering effect of carnitine in patients with type- IV hyperlipoproteinaemia. Lancet. 1978 Oct 14;2(8094):805.
Kraemer WJ, Volek JS . The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery. J Strength Cond Res. 2003 Aug; 17(3): 455-62.
Marconi C, Sassi G. Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes. Eur J Appl Physiol Occup Physiol. 1985;54(2):131-5.
Wyss V, Ganzit GP. Effects of L-carnitine administration on VO2max and the aerobicanaerobic threshold in normoxia and acute hypoxia.
Rossi CS, Siliprandi N. Effect of carnitine on serum HDL-cholesterol: report of two cases. Johns Hopkins Med J. 1982 Feb;150(2):51-4.
Pola P. Statistical evaluationof long term L-Carnitine therapy in hyperlypoproteinemias. Drugs Exp Clin Res 19839:925-934)
PolaP. Carnitine in the therapy of dyslipidemic patients. Curr Ther Res 1980; 27:208-215.
More Info
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